![]() The researchers first inserted two human gene segments into the mice. ![]() The modified model mimics - and refines - the trial-and-error process our own immune systems use to create increasingly effective antibodies when we encounter an invader. These mice essentially have built-in human immune systems. Sai Luo at Boston Children’s, the team first modified a mouse model the Alt lab created to search for broadly neutralizing antibodies to HIV, another virus that frequently mutates. “If it does, it might provide a new therapeutic and also contribute to new vaccine strategies.” Creating and testing multiple antibodies Frederick Alt of the Program in Cellular and Molecular Medicine at Boston Children’s, a senior investigator on the study. “We hope this antibody will prove to be as effective in patients as it has been in pre-clinical evaluations thus far,” says Dr. In lab tests, it neutralized all currently known SARS-CoV-2 variants of concern, including all Omicron variants. ![]() Scientists have been searching for an antibody that would be broadly neutralizing - able to fight off any virus variant that might emerge.Īn antibody developed by researchers at Boston Children’s Hospital now seems to fit the bill. ![]() As a result, we’ve seen breakthrough cases, antibody treatments that once worked have also become less effective over time. Gracey, Boston Children’s Hospital)Īs the COVID-19 pandemic wears on, newer variants of the SARS-CoV-2 coronavirus have been evolving ways to evade the antibodies we make in response to vaccines or prior infections. Researchers hope the discovery will lead to better COVID-19 vaccines and treatments. ![]()
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